<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Truncation Time Selection for Average Hazard Analyses</dc:title>
  <dc:title>R package AHTauDesign version 0.1.0</dc:title>
  <dc:description>
    Implements a two-stage, design-informed framework for selecting the
    truncation time in time-to-event trials analyzed with the average hazard
    estimand, motivated by pediatric oncology settings with small samples,
    slow accrual, and limited follow-up. Stage 1 validates a clinically
    proposed truncation time against the planned design using simulation-based
    diagnostics for risk-set support, follow-up coverage, estimability, and
    estimator stability, classifying it as Pass, Borderline, or Fail. Stage 2
    performs constrained optimization over a grid of candidate truncation
    times within a clinical-distance window, maximizing a utility subject to
    feasibility constraints, with an independent evaluation run to assess
    the selected time. Supports proportional-hazards, early-, and delayed-effect
    patterns, uniform accrual with administrative censoring, and
    calibrated exponential random censoring.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.1.0)</dc:relation>
  <dc:relation>Imports: survival, stats, utils</dc:relation>
  <dc:relation>Suggests: ggplot2, knitr, rmarkdown</dc:relation>
  <dc:creator>Xinyue Zhao &lt;xinyuezhao27@gwu.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Xinyue Zhao [aut, cre],
  Haitao Pan [aut]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-09-10</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=AHTauDesign</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.AHTauDesign</dc:identifier>
</oai_dc:dc>
