idd35 {gmvalid} | R Documentation |
Loci Idd3 and Idd5 are suspectable to be associated with type 1 diabetes. This data reflects an animal experiment from Hill et al. (2000).
data(idd35)
A data frame with 313 observations on the following 3 variables.
idd3
NN
and BB
idd5
NN
and BB
group
controls
cases
Data was used from Cordell et al. (2001) to model the joint effect of alleles at the loci Idd3 and Idd5 on the outcome "type 1 diabetes". Only homozygeous genotypes were available.
Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS and Peterson LB (2000) NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes, 49:1744-1747.
Cordell HJ, Todd JA, Hill NJ, Lord CJ, Lyons PA, Peterson LB, Wicker LS and Clayton DG (2001) Statistical modeling of interlocus interactions in a complex disease: Rejection of the multiplicative model of epistasis in type 1 diabetes. Genetics, 158:357-367.
data(idd35) table(idd35)