idd35 {gmvalid}R Documentation

Type 1 Diabetes susceptibility loci Idd3 and Idd5

Description

Loci Idd3 and Idd5 are suspectable to be associated with type 1 diabetes. This data reflects an animal experiment from Hill et al. (2000).

Usage

data(idd35)

Format

A data frame with 313 observations on the following 3 variables.

idd3
a factor with levels NN and BB
idd5
a factor with levels NN and BB
group
a factor with levels controls cases

Details

Data was used from Cordell et al. (2001) to model the joint effect of alleles at the loci Idd3 and Idd5 on the outcome "type 1 diabetes". Only homozygeous genotypes were available.

Source

Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS and Peterson LB (2000) NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans. Diabetes, 49:1744-1747.

References

Cordell HJ, Todd JA, Hill NJ, Lord CJ, Lyons PA, Peterson LB, Wicker† LS and Clayton DG (2001) Statistical modeling of interlocus interactions in a complex disease: Rejection of the multiplicative model of epistasis in type 1 diabetes. Genetics, 158:357-367.

Examples

  data(idd35)
  table(idd35)

[Package gmvalid version 1.0 Index]