Validate candidates and filter motifs

Check the occurrences

We must now validate these candidates. To do this, we will use as a restriction the occurrences. There are 2 types of occurrences in our approach : Global occurrences (GO) and Spatial occurrences (SO)

There is possibility to set the filtering with 2 parameters :

• Sigma : threshold of the global occurrences
• Kappa : threshold of the spatial occurrences

Here an example with 3 scenarios :

• Scenario 1 : kappa = sigma = 4
• Scenario 2 : kappa = sigma = 8
• Scenario 3 : kappa = sigma = 12

Filter motifs

Filter motifs by removing isolated motifs and rechecking occurrences.

To found these isolated motifs we use the cluster method.

If the motif does not have a neighbor then it is deleted. After that when all isolated motifs are deleted, we recheck like the previous step the occurrences.