Stress-Test a Pre-Specified Mixed Model for Repeated Measures

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Documentation for package ‘ballast’ version 0.6.1

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

default_inference	Default inference settings for 'stress_inference()'
mask_ids	Mask subject identifiers in a census
plot.stress_census	Plot a census: one row per family on the percent-of-base axis
plot.stress_design	Plot power and robustness power against the sample size
plot_pcdf	Empirical distribution of the p-values across a census
plot_pcurve	Plot p-value curves over a continuous perturbation
plot_pstrip	Strip plot of p-values after each deletion
plot_swarm	Bubble-swarm plot of a census against the no-difference line
print.stress_design	Size a trial for a robust result
run_plan	Run a pre-specified stress test
run_plans	Run several plans (several endpoints or comparisons) and compare
simulate_trial	Simulate a two-arm longitudinal trial
spec_update	Modify a stress spec
standard_plan	The standard stress test
stress_calibrate	Pre-trial calibration of the stress test
stress_census	Assemble a census of perturbations against the base analysis
stress_covariance	Perturbation family: within-subject covariance structure
stress_covariates	Perturbation family: covariate set
stress_curve	Perturbation family: a curve over a continuous data perturbation
stress_data	Perturbation family: alternative analysis data sets
stress_design	Size a trial for a robust result
stress_estimand	Perturbation family: intercurrent-event strategies (ICH E9(R1))
stress_estimator	Perturbation family: estimator class
stress_explain	Explain why an alternative analysis moved
stress_fit	Fit one MMRM and return one row
stress_fragility	Smallest set of subjects whose removal changes the conclusion
stress_grid	Perturbation family: crossed specification grid
stress_html	Interactive HTML report
stress_inference	Perturbation family: degrees-of-freedom method and variance estimator
stress_log	Write the run log for an audit trail
stress_loo	Perturbation family: leave-one-out deletions
stress_permute	Perturbation family: re-randomisation (permutation) test
stress_plan	Pre-specify a stress test
stress_population	Perturbation family: analysis population
stress_ranktest	Perturbation family: rank tests at the contrast visit
stress_reference	Perturbation family: reference-based multiple imputation
stress_report	Write a stress-test report
stress_sap	Statistical-analysis-plan text for a stress test
stress_spec	Define the pre-specified MMRM to stress-test
stress_spec_adam	Build a stress spec from an ADaM basic data structure
stress_spec_mmrm	Build a stress spec from a fitted mmrm model
stress_tables	Write regulatory-style tables and the census
stress_tipping	Perturbation family: delta-adjusted multiple imputation (tipping point)
stress_verdict	Classify the census: robust, sensitive or fragile, and marginal
stress_visits	Perturbation family: the contrast at every visit
stress_weights	Perturbation family: least-squares-mean weighting
summary.stress_census	Summarise a census by family
tipping_point	Find where a p-value curve crosses alpha