# Population Fisher Information Matrix

## Documentation for package ‘PFIM’ version 6.0.3

- DESCRIPTION file.
- User guides, package vignettes and other documentation.

## Help Pages

A B C D E F G I L M N O P R S misc

PFIM-package | Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.

## -- A --

addModel | Add a model to a library of models.
addModel-method | Add a model to a library of models.
addModels | Add a models to a library of models.
addModels-method | Add a models to a library of models.
Administration | Class "Administration"
Administration-class | Class "Administration"
AdministrationConstraints | Class "AdministrationConstraints"
AdministrationConstraints-class | Class "AdministrationConstraints"
Arm | Class "Arm"
Arm-class | Class "Arm"

## -- B --

BayesianFim | Class "BayesianFim"
BayesianFim-class | Class "BayesianFim"

## -- C --

checkSamplingTimeConstraintsForContinuousOptimization | Check for the samplingTime constraints for continuous optimization
checkSamplingTimeConstraintsForContinuousOptimization-method | Check for the samplingTime constraints for continuous optimization
checkValiditySamplingConstraint | checkValiditySamplingConstraint
checkValiditySamplingConstraint-method | checkValiditySamplingConstraint
Combined1 | Class "Combined1"
Combined1-class | Class "Combined1"
Constant | Class "Constant"
Constant-class | Class "Constant"
convertPKModelAnalyticToPKModelODE | Convert an analytic model to a ode model.
convertPKModelAnalyticToPKModelODE-method | Convert an analytic model to a ode model.

## -- D --

defineModel | Define a model.
defineModel-method | Define a model.
defineModelFromLibraryOfModels | Define a model from the library of models.
defineModelFromLibraryOfModels-method | Define a model from the library of models.
defineModelType | Define the type of a model.
defineModelType-method | Define the type of a model.
defineModelUserDefined | Define a user defined model.
defineModelUserDefined-method | Define a user defined model.
definePKModel | Define a PK model.
definePKModel-method | Define a PK model.
definePKPDModel | Define a PKPD model.
definePKPDModel-method | Define a PKPD model.
Design | Class "Design"
Design-class | Class "Design"
Distribution | Class "Distribution"
Distribution-class | Class "Distribution"

## -- E --

EvaluateArm | EvaluateArm
EvaluateArm-method | EvaluateArm
EvaluateDesign | EvaluateDesign
EvaluateDesign-method | EvaluateDesign
EvaluateErrorModelDerivatives | Evaluate the error model derivatives.
EvaluateErrorModelDerivatives-method | Evaluate the error model derivatives.
EvaluateFisherMatrix | Evaluate the Fisher matrix ( population, individual and Bayesian )
EvaluateFisherMatrix-method | Evaluate the Fisher matrix ( population, individual and Bayesian )
EvaluateModel | Evaluate a model.
EvaluateModel-method | Evaluate a model.
EvaluateVarianceFIM | Evaluate the variance of the Fisher information matrix.
EvaluateVarianceFIM-method | Evaluate the variance of the Fisher information matrix.
EvaluateVarianceModel | Evaluate the variance of a model.
EvaluateVarianceModel-method | Evaluate the variance of a model.
Evaluation | Class "Evaluation"
Evaluation-class | Class "Evaluation"

## -- F --

FedorovWynnAlgorithm | Class "FedorovWynnAlgorithm"
FedorovWynnAlgorithm-class | Class "FedorovWynnAlgorithm"
FedorovWynnAlgorithm_Rcpp | Fedorov-Wynn algorithm in Rcpp.
Fim | Class "Fim"
Fim-class | Class "Fim"
fisher.simplex | Compute the fisher.simplex
fun.amoeba | function fun.amoeba

## -- G --

generateFimsFromConstraints | Generate the fim from the constraints
generateFimsFromConstraints-method | Generate the fim from the constraints
generateReportEvaluation | Generate the report for the evaluation
generateReportEvaluation-method | Generate the report for the evaluation
generateReportOptimization | Generate report for the optimization.
generateReportOptimization-method | Generate report for the optimization.
generateSamplingsFromSamplingConstraints | Generate samplings from sampling constraints
generateSamplingsFromSamplingConstraints-method | Generate samplings from sampling constraints
generateTables | Generate the tables for the report.
generateTables-method | Generate the tables for the report.
getAdjustedGradient | getAdjustedGradient
getAdjustedGradient-method | getAdjustedGradient
getAdministration | getAdministration
getAdministration-method | getAdministration
getAdministrationConstraint | getAdministrationConstraint
getAdministrationConstraint-method | getAdministrationConstraint
getAdministrations | getAdministrations
getAdministrations-method | getAdministrations
getAdministrationsConstraints | getAdministrationsConstraints
getAdministrationsConstraints-method | getAdministrationsConstraints
getArms | Get the arms of an object.
getArms-method | Get the arms of an object.
getcError | Get the parameter c.
getcError-method | Get the parameter c.
getColumnAndParametersNamesFIM | Get the names of the names of the parameters associated to each column of the fim.
getColumnAndParametersNamesFIM-method | Get the names of the names of the parameters associated to each column of the fim.
getColumnAndParametersNamesFIMInLatex | Get the names of the names of the parameters associated to each column of the fim in Latex format.
getColumnAndParametersNamesFIMInLatex-method | Get the names of the names of the parameters associated to each column of the fim in Latex format.
getConditionNumberFixedEffects | Get the condition number of the matrix of the fixed effects.
getConditionNumberFixedEffects-method | Get the condition number of the matrix of the fixed effects.
getConditionNumberVarianceEffects | Get the condition number of the matrix of the variance effects.
getConditionNumberVarianceEffects-method | Get the condition number of the matrix of the variance effects.
getContent | Get content of a library of models.
getContent-method | Get content of a library of models.
getCorrelationMatrix | Get the correlation matrix.
getCorrelationMatrix-method | Get the correlation matrix.
getDataFrameResults | Get the dataframe of the results.
getDataFrameResults-method | Get the dataframe of the results.
getDcriterion | Get the D criterion of the fim.
getDcriterion-method | Get the D criterion of the fim.
getDelta | Get the parameter delta
getDelta-method | Get the parameter delta
getDerivatives | Get the derivatives of the model error equation.
getDerivatives-method | Get the derivatives of the model error equation.
getDescription | Get the description of a model.
getDescription-method | Get the description of a model.
getDesigns | Get the designs.
getDesigns-method | Get the designs.
getDeterminant | Get the determinant of the fim.
getDeterminant-method | Get the determinant of the fim.
getDistribution | Get the distribution.
getDistribution-method | Get the distribution.
getDose | getDose
getDose-method | getDose
getEigenValues | Get the eigenvalues of the fim.
getEigenValues-method | Get the eigenvalues of the fim.
getElementaryProtocols | Get the elementary protocols.
getElementaryProtocols-method | Get the elementary protocols.
getEquation | Get the equation of a model error.
getEquation-method | Get the equation of a model error.
getEquations | Get the equations of a model.
getEquations-method | Get the equations of a model.
getEquationsAfterInfusion | Get the equations after infusion.
getEquationsAfterInfusion-method | Get the equations after infusion.
getEquationsDuringInfusion | Get the equations during infusion.
getEquationsDuringInfusion-method | Get the equations during infusion.
getEvaluationFIMResults | Get the results of the evaluation.
getEvaluationFIMResults-method | Get the results of the evaluation.
getEvaluationInitialDesignResults | Get the evaluation results of the initial design.
getEvaluationInitialDesignResults-method | Get the evaluation results of the initial design.
getFim | getFim
getFim-method | getFim
getFisherMatrix | Get the FIM.
getFisherMatrix-method | Get the FIM.
getFixedEffects | Get the matrix of fixed effects.
getFixedEffects-method | Get the matrix of fixed effects.
getFixedMu | Get the fixed effect.
getFixedMu-method | Get the fixed effect.
getFixedOmega | Get the fixed variance.
getFixedOmega-method | Get the fixed variance.
getFixedParameters | Get the fixed parameters.
getFixedParameters-method | Get the fixed parameters.
getFixedTimes | Get the fixed sampling times.
getFixedTimes-method | Get the fixed sampling times.
getInitialConditions | getInitialConditions
getInitialConditions-method | getInitialConditions
getIterationAndCriteria | Get the iteration with the convergence criteria.
getIterationAndCriteria-method | Get the iteration with the convergence criteria.
getLambda | Get the parameter lambda.
getLambda-method | Get the parameter lambda.
getLibraryPDModels | Get the library of PD models.
getLibraryPDModels-method | Get the library of PD models.
getLibraryPKModels | Get the library of PK models.
getLibraryPKModels-method | Get the library of PK models.
getMinSampling | Get the minimal sampling times.
getMinSampling-method | Get the minimal sampling times.
getModel | Get the model.
getModel-method | Get the model.
getModelEquations | Get the model equations.
getModelEquations-method | Get the model equations.
getModelError | Get the model error.
getModelError-method | Get the model error.
getModelErrorParametersValues | Get the values of the model error parameters.
getModelErrorParametersValues-method | Get the values of the model error parameters.
getModelFromLibrary | Get a model from the library of models.
getModelFromLibrary-method | Get a model from the library of models.
getModelParameters | Get the model parameters.
getModelParameters-method | Get the model parameters.
getModelParametersValues | Get the values of the model parameters.
getModelParametersValues-method | Get the values of the model parameters.
getMu | getMu
getMu-method | getMu
getName | getName
getName-method | getName
getNames | getNames
getNames-method | getNames
getNumberOfArms | getNumberOfArms
getNumberOfArms-method | getNumberOfArms
getNumberOfIterations | Get the number of iterations.
getNumberOfIterations-method | Get the number of iterations.
getNumberOfParameters | Get the number of parameters.
getNumberOfParameters-method | Get the number of parameters.
getNumberOfsamplingsOptimisable | Get the number of sampling times that are optimisable.
getNumberOfsamplingsOptimisable-method | Get the number of sampling times that are optimisable.
getNumberOfTimesByWindows | Get the number of sampling times by windows.
getNumberOfTimesByWindows-method | Get the number of sampling times by windows.
getOdeSolverParameters | getOdeSolverParameters
getOdeSolverParameters-method | getOdeSolverParameters
getOmega | Get the matrix omega of an object.
getOmega-method | Get the matrix omega of an object.
getOptimalDesign | Get the optimal design.
getOptimalDesign-method | Get the optimal design.
getOptimalFrequencies | Get the optimal frequencies
getOptimalFrequencies-method | Get the optimal frequencies
getOptimalWeights | Get the optimal weights.
getOptimalWeights-method | Get the optimal weights.
getOptimizationResults | Get the optimization results.
getOptimizationResults-method | Get the optimization results.
getOptimizer | Get the optimization algorithm.
getOptimizer-method | Get the optimization algorithm.
getOptimizerParameters | Get the optimization parameters.
getOptimizerParameters-method | Get the optimization parameters.
getOutcome | getOutcome
getOutcome-method | getOutcome
getOutcomes | Get the outcomes of a model.
getOutcomes-method | Get the outcomes of a model.
getOutcomesEvaluation | getOutcomesEvaluation
getOutcomesEvaluation-method | getOutcomesEvaluation
getOutcomesForEvaluation | Get the outcomes of a model used for the evaluation (is scales outcomes).
getOutcomesForEvaluation-method | Get the outcomes of a model used for the evaluation (is scales outcomes).
getOutcomesGradient | getOutcomesGradient
getOutcomesGradient-method | getOutcomesGradient
getParameters | Get the parameters of an object.
getParameters-method | Get the parameters of an object.
getPDModel | Get a PD model.
getPDModel-method | Get a PD model.
getPKModel | Get a PK model.
getPKModel-method | Get a PK model.
getPKPDModel | Get a PKPD model.
getPKPDModel-method | Get a PKPD model.
getPlotOptions | Get the plot options for graphs responses and SI
getProportionsOfSubjects | Get the proportion of subjects.
getProportionsOfSubjects-method | Get the proportion of subjects.
getRSE | Get the RSE
getRSE-method | Get the RSE
getSamplings | Get the sampling of an object.
getSamplings-method | Get the sampling of an object.
getSamplingsWindows | Get the windows for the sampling times.
getSamplingsWindows-method | Get the windows for the sampling times.
getSamplingTime | getSamplingTime
getSamplingTime-method | getSamplingTime
getSamplingTimeConstraint | getSamplingTimeConstraint
getSamplingTimeConstraint-method | getSamplingTimeConstraint
getSamplingTimes | getSamplingTimes
getSamplingTimes-method | getSamplingTimes
getSamplingTimesConstraints | getSamplingTimesConstraints
getSamplingTimesConstraints-method | getSamplingTimesConstraints
getSE | Get the SE.
getSE-method | Get the SE.
getShrinkage | Get the shrinkage.
getShrinkage-method | Get the shrinkage.
getSigmaInter | Get the parameter sigma inter.
getSigmaInter-method | Get the parameter sigma inter.
getSigmaSlope | Get the parameter sigma slope.
getSigmaSlope-method | Get the parameter sigma slope.
getSize | getSize
getSize-method | getSize
getTau | getTau
getTau-method | getTau
getTimeDose | getTimeDose
getTimeDose-method | getTimeDose
getTinf | Get the infusion duration.
getTinf-method | Get the infusion duration.
getVarianceEffects | Get the matrix of the variance effects.
getVarianceEffects-method | Get the matrix of the variance effects.

## -- I --

IndividualFim | Class "Fim"
IndividualFim-class | Class "Fim"
isDoseInEquations | Test if the dose is in the equations of the model.
isDoseInEquations-method | Test if the dose is in the equations of the model.
isModelAnalytic | Test if a mode is analytic.
isModelAnalytic-method | Test if a mode is analytic.
isModelBolus | Test if a mode is bolus.
isModelBolus-method | Test if a mode is bolus.
isModelInfusion | Test if a mode is infusion
isModelInfusion-method | Test if a mode is infusion
isModelODE | Test if a mode is ode.
isModelODE-method | Test if a mode is ode.
isModelSteadyState | Test if a mode is steady state.
isModelSteadyState-method | Test if a mode is steady state.

## -- L --

LibraryOfModels | Class "LibraryOfModels"
LibraryOfModels-class | Class "LibraryOfModels"
LibraryOfPDModels | Library of the PK models
LibraryOfPKModels | Library of the PK models
LibraryOfPKPDModels | Class "LibraryOfPKPDModels"
LibraryOfPKPDModels-class | Class "LibraryOfPKPDModels"
LogNormal | Class "LogNormal"
LogNormal-class | Class "LogNormal"

## -- M --

Model | Class "Model"
Model-class | Class "Model"
ModelAnalytic | Class "ModelAnalytic"
ModelAnalytic-class | Class "ModelAnalytic"
ModelAnalyticBolus | Class "ModelAnalyticBolus"
ModelAnalyticBolus-class | Class "ModelAnalyticBolus"
ModelAnalyticBolusSteadyState | Class "ModelAnalyticBolusSteadyState"
ModelAnalyticBolusSteadyState-class | Class "ModelAnalyticBolusSteadyState"
ModelAnalyticInfusion | Class "ModelAnalyticInfusion"
ModelAnalyticInfusion-class | Class "ModelAnalyticInfusion"
ModelAnalyticInfusionSteadyState | Class "ModelAnalyticInfusionSteadyState"
ModelAnalyticInfusionSteadyState-class | Class "ModelAnalyticInfusionSteadyState"
ModelAnalyticSteadyState | Class "ModelAnalyticSteadyState"
ModelAnalyticSteadyState-class | Class "ModelAnalyticSteadyState"
ModelBolus | Class "ModelBolus"
ModelBolus-class | Class "ModelBolus"
ModelError | Class "ModelError" representing a Model error.
ModelError-class | Class "ModelError" representing a Model error.
ModelInfusion | Class "ModelInfusion"
ModelInfusion-class | Class "ModelInfusion"
ModelODE | Class "ModelODE"
ModelODE-class | Class "ModelODE"
ModelODEBolus | Class "ModelODEBolus"
ModelODEBolus-class | Class "ModelODEBolus"
ModelODEDoseInEquations | Class "ModelODEDoseInEquations"
ModelODEDoseInEquations-class | Class "ModelODEDoseInEquations"
ModelODEDoseNotInEquations | Class "ModelODEDoseNotInEquations"
ModelODEDoseNotInEquations-class | Class "ModelODEDoseNotInEquations"
ModelODEInfusion | Class "ModelODEInfusion"
ModelODEInfusion-class | Class "ModelODEInfusion"
ModelODEInfusionDoseInEquations | Class "ModelODEInfusionDoseInEquations"
ModelODEInfusionDoseInEquations-class | Class "ModelODEInfusionDoseInEquations"
ModelParameter | Class "ModelParameter"
ModelParameter-class | Class "ModelParameter"
MultiplicativeAlgorithm | Class "MultiplicativeAlgorithm"
MultiplicativeAlgorithm-class | Class "MultiplicativeAlgorithm"
MultiplicativeAlgorithm_Rcpp | Function MultiplicativeAlgorithm_Rcpp

## -- N --

Normal | Class "Normal"
Normal-class | Class "Normal"

## -- O --

Optimization | Class "Optimization"
Optimization-class | Class "Optimization"
OptimizationAlgorithm | Class "OptimizationAlgorithm"
OptimizationAlgorithm-class | Class "OptimizationAlgorithm"
optimize | Optimize a design.
optimize-method | Optimize a design.

## -- P --

package-PFIM | Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.
parametersForComputingGradient | Define the parameters for computing the gradients of a model.
parametersForComputingGradient-method | Define the parameters for computing the gradients of a model.
PFIM, | Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.
PFIMProject | Class "PFIMProject"
PFIMProject-class | Class "PFIMProject"
PGBOAlgorithm | Class "PGBOAlgorithm"
PGBOAlgorithm-class | Class "PGBOAlgorithm"
PlotEvaluation | Class "PlotEvaluation"
plotEvaluation | Graphs of the results of the evaluation.
PlotEvaluation-class | Class "PlotEvaluation"
plotEvaluation-method | Graphs of the results of the evaluation.
plotFrequencies | Graph of the frequencies for the FW algorithm.
plotFrequencies-method | Graph of the frequencies for the FW algorithm.
plotOutcomesEvaluation | plotOutcomesEvaluation
plotOutcomesEvaluation-method | plotOutcomesEvaluation
plotOutcomesGradient | plotOutcomesGradient
plotOutcomesGradient-method | plotOutcomesGradient
plotRSE | Graph of the RSE.
plotRSE-method | Graph of the RSE.
plotSE | Graph the SE.
plotSE-method | Graph the SE.
plotSensitivityIndice | Graphs of the results of the evaluation.
plotSensitivityIndice-method | Graphs of the results of the evaluation.
plotShrinkage | Graph of the shrinkage.
plotShrinkage-method | Graph of the shrinkage.
plotWeights | Graph of the weights for the multiplicative algorithm.
plotWeights-method | Graph of the weights for the multiplicative algorithm.
PopulationFim | Class "PopulationFim"
PopulationFim-class | Class "PopulationFim"
Proportional | Class "Proportional"
Proportional-class | Class "Proportional"
PSOAlgorithm | Class "PSOAlgorithm"
PSOAlgorithm-class | Class "PSOAlgorithm"

## -- R --

Report | Report
Report-method | Report
reportTablesAdministration | reportTablesAdministration
reportTablesAdministration-method | reportTablesAdministration
reportTablesDesign | reportTablesDesign
reportTablesDesign-method | reportTablesDesign
reportTablesFIM | Generate the tables for the report.
reportTablesFIM-method | Generate the tables for the report.
reportTablesModelError | Generate the tables for model errors for the evaluation report.
reportTablesModelError-method | Generate the tables for model errors for the evaluation report.
reportTablesModelParameters | Generate the tables for model parameters for the evaluation report.
reportTablesModelParameters-method | Generate the tables for model parameters for the evaluation report.
reportTablesPlot | reportTablesPlot
reportTablesPlot-method | reportTablesPlot
reportTablesSamplingConstraints | reportTablesSamplingConstraints
reportTablesSamplingConstraints-method | reportTablesSamplingConstraints
resizeFisherMatrix | Resize the fisher Matrix from a vector to a matrix.
resizeFisherMatrix-method | Resize the fisher Matrix from a vector to a matrix.
run | run
run-method | run

## -- S --

SamplingTimeConstraints | Class "SamplingTimeConstraints"
SamplingTimeConstraints-class | Class "SamplingTimeConstraints"
SamplingTimes | Class "SamplingTimes"
SamplingTimes-class | Class "SamplingTimes"
setAdministrations | setAdministrations
setAdministrations-method | setAdministrations
setArm | setArm
setArm-method | setArm
setArms | Set the arms of an object.
setArms-method | Set the arms of an object.
setcError | Set the parameter c.
setcError-method | Set the parameter c.
setContent | Set content of a library of models.
setContent-method | Set content of a library of models.
setDerivatives | Set the derivatives of the model error equation.
setDerivatives-method | Set the derivatives of the model error equation.
setDescription | Set the description of a model.
setDescription-method | Set the description of a model.
setDesigns | Set the designs.
setDesigns-method | Set the designs.
setDistribution | Set the distribution.
setDistribution-method | Set the distribution.
setDose | Set the amount of dose
setDose-method | Set the amount of dose
setEquation | Set the equation of a model error.
setEquation-method | Set the equation of a model error.
setEquations | Set the equations of a model.
setEquations-method | Set the equations of a model.
setEquationsAfterInfusion | Set the equations after infusion.
setEquationsAfterInfusion-method | Set the equations after infusion.
setEquationsDuringInfusion | Set the equations during infusion.
setEquationsDuringInfusion-method | Set the equations during infusion.
setEvaluationFIMResults | Set the evaluation results.
setEvaluationFIMResults-method | Set the evaluation results.
setEvaluationInitialDesignResults | Set the evaluation results of the initial design.
setEvaluationInitialDesignResults-method | Set the evaluation results of the initial design.
setFim | setFim
setFim-method | setFim
setFimTypeToString | Convert the type of the object fim to a string.
setFimTypeToString-method | Convert the type of the object fim to a string.
setFisherMatrix | Set the FIM.
setFisherMatrix-method | Set the FIM.
setFixedEffects | Set the fixed effects.
setFixedEffects-method | Set the fixed effects.
setFixedMu | Set the mu as fixed or not.
setFixedMu-method | Set the mu as fixed or not.
setFixedOmega | Set the omega as fixed of not.
setFixedOmega-method | Set the omega as fixed of not.
setInitialConditions | setInitialConditions
setInitialConditions-method | setInitialConditions
setIterationAndCriteria | Set the iteration with the convergence criteria.
setIterationAndCriteria-method | Set the iteration with the convergence criteria.
setModel | Set the model.
setModel-method | Set the model.
setModelError | Set the model error.
setModelError-method | Set the model error.
setModelFromLibrary | Set a model from the library of model
setModelFromLibrary-method | Set a model from the library of model
setMu | Set the value of the fixed effect mu of an object.
setMu-method | Set the value of the fixed effect mu of an object.
setName | Set the name of an object.
setName-method | Set the name of an object.
setNumberOfArms | setNumberOfArms
setNumberOfArms-method | setNumberOfArms
setOdeSolverParameters | Set the parameters of the ode solver.
setOdeSolverParameters-method | Set the parameters of the ode solver.
setOmega | Set the matrix omega of an object.
setOmega-method | Set the matrix omega of an object.
setOptimalDesign | Set the optimal design.
setOptimalDesign-method | Set the optimal design.
setOptimalWeights | Set the optimal weights.
setOptimalWeights-method | Set the optimal weights.
setOptimizationResults | Set the optimization results.
setOptimizationResults-method | Set the optimization results.
setOutcome | setOutcome
setOutcome-method | setOutcome
setOutcomes | Set the outcomes of a model.
setOutcomes-method | Set the outcomes of a model.
setOutcomesEvaluation | setOutcomesEvaluation
setOutcomesEvaluation-method | setOutcomesEvaluation
setOutcomesForEvaluation | Set the outcomes of a model used for the evaluation (is scales outcomes).
setOutcomesForEvaluation-method | Set the outcomes of a model used for the evaluation (is scales outcomes).
setOutcomesGradient | setOutcomesGradient
setOutcomesGradient-method | setOutcomesGradient
setParameters | Set the parameters of an object.
setParameters-method | Set the parameters of an object.
setSamplingConstraintForOptimization | setSamplingConstraintForOptimization
setSamplingConstraintForOptimization-method | setSamplingConstraintForOptimization
setSamplings | Set the sampling times.
setSamplings-method | Set the sampling times.
setSamplingTime | setSamplingTime
setSamplingTime-method | setSamplingTime
setSamplingTimes | setSamplingTimes
setSamplingTimes-method | setSamplingTimes
setSamplingTimesConstraints | setSamplingTimesConstraints
setSamplingTimesConstraints-method | setSamplingTimesConstraints
setShrinkage | Set the shrinkage.
setShrinkage-method | Set the shrinkage.
setSigmaInter | Set the parameter sigma inter.
setSigmaInter-method | Set the parameter sigma inter.
setSigmaSlope | Set the parameter sigma slope.
setSigmaSlope-method | Set the parameter sigma slope.
setSize | setSize
setSize-method | setSize
setTau | setTau
setTau-method | setTau
setTimeDose | setTimeDose
setTimeDose-method | setTimeDose
setTinf | Set the infusion duration.
setTinf-method | Set the infusion duration.
setVarianceEffects | Set the matrix of the variance effects.
setVarianceEffects-method | Set the matrix of the variance effects.
show-method | show
SimplexAlgorithm | Class "SimplexAlgorithm"
SimplexAlgorithm-class | Class "SimplexAlgorithm"

## -- misc --

_PACKAGE | Fisher Information matrix for design evaluation/optimization for nonlinear mixed effects models.