CFO-Type Designs in Phase I/II Clinical Trials

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Documentation for package ‘CFO’ version 2.0.0

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aCFO.next Determination of the dose level for next cohort in the accumulative calibration-free odds (aCFO) design for phase I trials
CFO.next Determination of the dose level for next cohort in the calibration-free odds (CFO) design for phase I trials
CFO.oc Generate operating characteristics of phase I trials single-drug trials in multiple simulations
CFO.selectmtd Select the maximum tolerated dose (MTD) for the real single-drug trials
CFO.simu Conduct one simulation using the calibration-free odds (CFO) or accumulative CFO (aCFO) design for phase I trials.
CFO2d.next Determinate the dose level for the next cohort in the two-dimensional calibration-free odds (2dCFO) design for phase I trials.
CFO2d.oc Generate operating characteristics of phase I drug-combination trials in multiple simulations
CFO2d.selectmtd Select the maximum tolerated dose (MTD) for the real drug combination trials
CFO2d.simu Conduct one simulation using the two-dimensional calibration-free odds (2dCFO) design for phase I trials.
CFOeff.next Determination of the dose level for next cohort in the calibration-free odds (CFO) design for phase I/II trials
CFOeff.oc Generate operating characteristics of phase I/II trials single-drug trials in multiple simulations.
CFOeff.simu Conduct one simulation using the calibration-free odds (CFO) design for phase I/II trials
lateonset.next Determination of the dose level for next cohort in the calibration-free odds type (CFO-type) design with late-onset toxicity for phase I trials
lateonset.simu Conduct one simulation using the calibration-free odds type (CFO-type) design with late-onset toxicity for phase I trials.
plot.cfo Plot the results by other functions
print.cfo Generate descriptive summary for objects returned by other functions
summary.cfo Generate descriptive summary for objects returned by other functions