The hardware and bandwidth for this mirror is donated by dogado GmbH, the Webhosting and Full Service-Cloud Provider. Check out our Wordpress Tutorial.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]dogado.de.
Implements estimation and testing procedures for evaluating an intermediate biomarker response as a principal surrogate of a clinical response to treatment (i.e., principal stratification effect modification analysis), as described in Juraska M, Huang Y, and Gilbert PB (2020), Inference on treatment effect modification by biomarker response in a three-phase sampling design, Biostatistics, 21(3): 545-560 <doi:10.1093/biostatistics/kxy074>. The methods avoid the restrictive 'placebo structural risk' modeling assumption common to past methods and further improve robustness by the use of nonparametric kernel smoothing for biomarker density estimation. A randomized controlled two-group clinical efficacy trial is assumed with an ordered categorical or continuous univariate biomarker response measured at a fixed timepoint post-randomization and with a univariate baseline surrogate measure allowed to be observed in only a subset of trial participants with an observed biomarker response (see the flexible three-phase sampling design in the paper for details). Bootstrap-based procedures are available for pointwise and simultaneous confidence intervals and testing of four relevant hypotheses. Summary and plotting functions are provided for estimation results.
| Version: | 1.0.3 |
| Imports: | graphics, stats, osDesign, np, chngpt, MASS |
| Suggests: | knitr, rmarkdown |
| Published: | 2020-11-18 |
| Author: | Michal Juraska [aut, cre] |
| Maintainer: | Michal Juraska <mjuraska at fredhutch.org> |
| BugReports: | https://github.com/mjuraska/pssmooth/issues |
| License: | GPL-2 |
| URL: | https://github.com/mjuraska/pssmooth |
| NeedsCompilation: | no |
| Citation: | pssmooth citation info |
| Materials: | README NEWS |
| CRAN checks: | pssmooth results |
| Reference manual: | pssmooth.pdf |
| Package source: | pssmooth_1.0.3.tar.gz |
| Windows binaries: | r-devel: pssmooth_1.0.3.zip, r-release: pssmooth_1.0.3.zip, r-oldrel: pssmooth_1.0.3.zip |
| macOS binaries: | r-release (arm64): pssmooth_1.0.3.tgz, r-oldrel (arm64): pssmooth_1.0.3.tgz, r-release (x86_64): pssmooth_1.0.3.tgz, r-oldrel (x86_64): pssmooth_1.0.3.tgz |
| Old sources: | pssmooth archive |
Please use the canonical form https://CRAN.R-project.org/package=pssmooth to link to this page.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.