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linpk

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An R package for generating concentration-time profiles from linear pharmacokinetic (PK) systems.

Installation

To install from CRAN:

install.packages("linpk")

To install the latest development version directly from GitHub:

require(devtools)
devtools::install_github("benjaminrich/linpk")

Basic Usage

To simulate a PK profile from a one-compartment model with first-order absorption under repeated dosing:

t.obs <- seq(0, 6*24, 0.5)
y <- pkprofile(t.obs, cl=0.5, vc=11, ka=1.3, dose=list(amt=100, addl=9, ii=12))
plot(y)
PK profile from a one-compartment model with first-order absorption under repeated dosing

For a more detailed introduction to the package, see the vignette.

Shiny App

There is a companion shiny app that provides a demo of the package capabilities, and also generates code that can be placed in an R script. It can be accessed at https://benjaminrich.shinyapps.io/linpk-demo-app/ or run locally by pasting the following lines in an R console:

# Make sure the required packages are installed (if not, install them)
sapply(c("shiny", "shinyjs", "shinyAce", "dygraphs", "linpk"), requireNamespace)
linpk::linpkApp()

The app will open in a browser, and looks like this:

Screenshot of the shiny app

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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