gst: Global Statistical Tests for Multiple Endpoints

Design and evaluate global statistical tests (GST) that combine several endpoints into one test, including O'Brien's ordinary and generalized least squares tests (O'Brien (1984) <doi:10.2307/2531158>), power and sample size calculations, and an O'Brien-based truncated closed testing procedure (Luo et al. (2025) <doi:10.1002/pst.70010>). Two 'shiny' applications support interactive power calculation and the creation of forest plots for multiple endpoints from summary statistics.

Version:	0.4.0
Depends:	R (≥ 4.1.0)
Imports:	dplyr, forestploter, magrittr, MASS, multcomp, stats, parallel, readr, rhandsontable, shiny, shinyWidgets, htmltools, tidyr, plotly, grDevices, grid, pwr, DT, purrr, tibble, bslib, bsicons, datapasta, sortable, stringr, rclipboard, ggplot2, mvtnorm, reactable, rlang
Suggests:	knitr, rmarkdown, gt, testthat (≥ 3.0.0)
Published:	2026-11-07
DOI:	10.32614/CRAN.package.gst
Author:	Lerong Li [aut, led], Anthony Pileggi [aut], Xiaolong Luo [aut], Xiao Ni [aut, cre], Sarepta Therapeutics Inc. [cph, fnd], Stephen Knapp [ctb], Preston Burns [ctb]
Maintainer:	Xiao Ni <mooncase at gmail.com>
BugReports:	https://github.com/xni7/gst/issues
License:	Apache License (== 2.0)
URL:	https://xni7.github.io/gst/, https://github.com/xni7/gst
NeedsCompilation:	no
Materials:	README, NEWS
CRAN checks:	gst results

Documentation:

Reference manual:	gst.html , gst.pdf
Vignettes:	Make Forestplot App (source, R code) GST Power App (source, R code) O'Brien's Test (source, R code) Reference for 'gst' package (source, R code)

Downloads:

Package source:	gst_0.4.0.tar.gz
Windows binaries:	r-devel: gst_0.4.0.zip, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): gst_0.4.0.tgz, r-oldrel (arm64): gst_0.4.0.tgz, r-release (x86_64): gst_0.4.0.tgz, r-oldrel (x86_64): gst_0.4.0.tgz

Linking:

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