dtpcrm: Dose Transition Pathways for Continual Reassessment Method

Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.

Version:	0.1.1
Imports:	diagram, dfcrm
Suggests:	knitr, rmarkdown, testthat
Published:	2019-08-20
Author:	Christina Yap [aut, cre], Daniel Slade [aut], Kristian Brock [aut], Yi Pan [aut]
Maintainer:	Christina Yap <yapchristina17 at gmail.com>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
CRAN checks:	dtpcrm results

Documentation:

Reference manual:	dtpcrm.pdf
Vignettes:	dtpcrm: Dose Transition Pathways with Continual Reassessment Method

Downloads:

Package source:	dtpcrm_0.1.1.tar.gz
Windows binaries:	r-devel: dtpcrm_0.1.1.zip, r-release: dtpcrm_0.1.1.zip, r-oldrel: dtpcrm_0.1.1.zip
macOS binaries:	r-release (arm64): dtpcrm_0.1.1.tgz, r-oldrel (arm64): dtpcrm_0.1.1.tgz, r-release (x86_64): dtpcrm_0.1.1.tgz, r-oldrel (x86_64): dtpcrm_0.1.1.tgz
Old sources:	dtpcrm archive

Linking:

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