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The goal of babelmixr2 is to convert nlmixr2 syntax to other commonly used tools.
You can install the released version of babelmixr2 from CRAN with:
You can install from r-universe by:
# Download and install babelmixr2 in R
install.packages('babelmixr2',
repos = c(
nlmixr2 = 'https://nlmixr2.r-universe.dev',
CRAN = 'https://cloud.r-project.org'))Otherwise you can always install from GitHub:
babelmixr2Babelmixr2 can help you by:
Running your nlmixr2 model in a commercial nonlinear mixed effects modeling tool like NONMEM or Monolix
Convert your NONMEM model to a nlmixr2 model (in conjunction with nonmem2rx)
Calculate scaling factors and automatically add initial conditions based on non-compartmental analysis (using PKNCA)
While not required, you can get/install the R ‘lixoftConnectors’ package in the ‘Monolix’ installation, as described at the following url https://monolix.lixoft.com/monolix-api/lixoftconnectors_installation/. When ‘lixoftConnectors’ is available, R can run ‘Monolix’ directly instead of using a command line.
After installed, if you use the standard interface, you can obtain new initial estimates with PKNCA:
mod <-
nlmixr2(
nlmixrFun, nlmmixrData, est = "pknca",
control = pkncaControl(concu = "ng/mL", doseu = "mg", timeu = "hr", volumeu = "L")
)or, you can convert to Monolix with
or, you can convert to NONMEM with
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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