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INLAjoint is a package that fits joint models for multivariate longitudinal markers (with various distributions available) and survival outcomes (possibly accounting for competing risks and multi-state) with Integrated Nested Laplace Approximations (INLA). The flexible and user friendly function joint() facilitates the use of the fast and reliable inference technique implemented in INLA package for joint modeling. More details are given in the help page of the joint function (accessible via ?joint in the R console), the vignette associated to the joint() function (accessible via vignette(“INLAjoint”) in the R console).
install.packages(“R.rsp”) # (only for the vignette)
devtools::install_github(‘DenisRustand/INLAjoint’, build_vignettes = TRUE)
Note that INLA is required, you can install it with: install.packages(“INLA”,repos=c(getOption(“repos”),INLA=“https://inla.r-inla-download.org/R/testing”), dep=TRUE)
More details at https://www.r-inla.org/download-install
Finally, it is possible to use this package with pardiso, which provides a high performance computing environment with parallel computing support using OpenMP (not avail. on windows). See https://pardiso-project.org/r-inla/ for more informations.
Contact: INLAjoint@gmail.com
References:
Rustand, D., van Niekerk, J., Krainski, E. T., & Rue, H. (2024). Joint Modeling of Multivariate Longitudinal and Survival Outcomes with the R package INLAjoint. arXiv preprint arXiv:2402.08335. https://arxiv.org/abs/2402.08335
Rustand, D., van Niekerk, J., Krainski, E. T., Rue, H., & Proust-Lima, C. (2023). Fast and flexible inference for joint models of multivariate longitudinal and survival data using integrated nested Laplace approximations. Biostatistics, kxad019. https://doi.org/10.1093/biostatistics/kxad019
Alvares, D., van Niekerk, J., Krainski, E. T., Rue, H., & Rustand, D. (2022). Bayesian survival analysis with INLA. arXiv preprint arXiv:2212.01900. https://arxiv.org/abs/2212.01900
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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